Please note that Grandaxin (Tofisopam) is not a dietary supplement. Read the information below carefully and consult your doctor before purchasing Grandaxin. Tofisopam is not approved for use in North America. Its R-enantiomer is in Phase II clinical trials for the treatment of irritable bowel syndrome. Synonyms Grandaxin, Emandaxin, Sériel Form: 20 pills of 50mg / 60 pills of 50mg Form description: Round, flat tablets of white or greyish-white color in the form of a disc, with a facet and a break line on one side and the engraving “GRANDAX” on the other side, without or with almost no smell. Active ingredient: Tofisopam—50 mg Excipients: Stearic acid, magnesium stearate, gelatin, talc, potato starch, lactose monohydrate, microcrystalline cellulose. CAS Number: 22345-47-7 ATC code: N05BA23 Pharmacological action: Anxiolytic Shelf life: 5 years. Do not use it beyond the expiration date printed on the package. Storage conditions: Store at temperatures no higher than 15-25°C (59-77°F). Keep in a safe place out of reach of children. Terms of release: Over-the-counter Manufacturer: EGIS Pharmaceuticals, Hungary What is Grandaxin (Tofisopam)? Tofisopam (Grandaxin) is a non-sedating daytime anxiolytic. It belongs to the 2,3-benzodiazepines family (also known as homophthalazines) and differs from typical benzodiazepine derivatives in its mechanism of action. What is Grandaxin (Tofisopam) Used For? Tofisopam can be used for the following conditions (according to the manufacturer): Neurosis, psychopathy, and other conditions accompanied by a feeling of emotional stress, anxiety, and fear; Reactive depression with mild psychopathic symptoms; Premenstrual syndrome, climacteric syndrome; Cardialgia (in the form of monotherapy or in combination with other drugs); Myasthenia gravis, myopathies, neurogenic muscular atrophies, and other pathological conditions with secondary neurotic symptoms when anxiolytics with a pronounced muscle relaxant effect are contraindicated; alcohol withdrawal syndrome; Alcohol withdrawal. More detailed information about the studies on the application can be found in the Research tab. What Are the Benefits and Effects of Grandaxin (Tofisopam)? Tofisopam provides anxiolytic effects without addiction risk or withdrawal syndrome. It has a mild stimulant action, does not impair cognitive function, and can enhance the effects of dopaminergic stimulants. Tofisopam does not have sedative, skeletal muscle relaxant, motor skill-impairing, anticonvulsant, or amnestic properties. Is Grandaxin (Tofisopam) Safe to Take? Tofisopam has the following contraindications: hypersensitivity to the active or any other ingredient of the medicine or to any other benzodiazepines; conditions accompanied by severe psychomotor agitation, aggressiveness or severe depression; decompensated respiratory failure; 1 trimester of pregnancy and breastfeeding; sleep apnea (in the anamnesis); simultaneous taking of tacrolimus, sirolimus, and cyclosporin; intolerance to galactose, congenital lactase insufficiency, or glucose and galactose malabsorption syndrome (the medicine contains lactose monohydrate). With caution: decompensated chronic respiratory distress, acute respiratory failure in the anamnesis, angle-closure glaucoma, epilepsy, organic brain lesions (such as atherosclerosis). Grandaxin review by Boost Your Biology Expert – Lucas Aoun! FAQ Is Grandaxin (Tofisopam) Addictive? Grandaxin (Tofisopam) doesn’t cause physical addiction, sedation, muscle relaxation, or potentiation of alcohol effects. It also doesn’t impair cognitive function, has no cardiotoxic effects, and even improves coronary blood flow and myocardial oxygen demand. Tolerance doesn’t develop with prolonged use, and withdrawal syndrome isn’t observed with tofisopam. It’s crucial to seek guidance from a certified healthcare provider before starting or stopping the administration of Grandaxin to guarantee the safe and efficient handling of anxiety symptoms. Where can I order Grandaxin (Tofisopam) Online? You can order Grandaxin online from different vendors. CosmicNootropic offers Grandaxin in packs of 20x50mg and 60x50mg tablets with worldwide shipping! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product. You can order Grandaxin and get it delivered to the USA, Europe, the UK, Asia, and many other destinations via CosmicNootropic. How does Grandaxin (Tofisopam) Interact with Other Drugs? Grandaxin (Tofisopam) may increase the plasma concentration of the drugs metabolized by CYP3A4. It does potentiate the effects of CNS depressants (e.g., analgesics, anesthetics, antidepressants, H1-antihistamines, sedatives, and antipsychotics). Hepatic enzyme inducers (alcohol, nicotine, barbiturates, anticonvulsants) may enhance the metabolism of Tofisopam, thus decreasing its efficacy. Some antifungal drugs (Ketoconazole, Itraconazole) may inhibit the metabolism of Tofisopam and increase its concentration in blood plasma. Some antihypertensive drugs (Clonidine, calcium channel blockers) may potentiate the effect of Tofisopam. Beta-blockers may inhibit the metabolism of the drug without affecting its efficacy significantly. Tofisopam may enhance plasma levels of Digoxin. Benzodiazepines may affect the anticoagulant effect of warfarin. Long-term treatment with disulfiram may inhibit the metabolism of Tofisopam. Antacids may affect the absorption of Tofisopam. Omeprazole and Cimetidine do inhibit the metabolism of Tofisopam. Oral contraceptives may inhibit the metabolism of Tofisopam. Tofisopam does decrease the depressant effect of alcohol on the central nervous system. How Does Grandaxin (Tofisopam) Work in the Brain? Grandaxin (Tofisopam) does not bind directly to benzodiazepine receptors but improves the binding of 1,4-benzodiazepines. It stimulates benzodiazepine receptors in the brain, increasing GABA receptor sensitivity, enhancing chloride channel activity, and reducing neuronal excitability. It also modulates dopaminergic and opioid neurotransmission and acts as a phosphodiesterase (PDE) inhibitor, particularly affecting PDE-4A1, PDE-10A1, PDE-3, and PDE-2A3, which may contribute to its antipsychotic effects. When Grandaxin (Tofisopam) Was First Synthesized? Tofisopam was first synthesized in 1966 in Hungary. It has been successfully used for anxiety management since the 1970s.
