Effex Tribulus is a herbal drug based on Tribulus Terrestris (sometimes called goat head, bullhead, small caltrops, cat head, devil’s eyelashes, or tackweed) stem and leaves extract containing steroid saponins. The drug has a tonic effect and it stimulates the reproductive system functions, improving sexual libido and prolonging erection in men. Tribulus Terrestris extract stimulates spermatogenesis, buy it to increase the number of spermatozoa and their mobility. Tribulus Terrestris has been used in traditional medicine in China, India, Sudan, Pakistan, and other countries for centuries. In India, the plant is used in the form of decoction to treat urinary tract infections, urolithiasis, dysmenorrhea, and edema. Scientific research based on World Health Organization criteria (published in Cryobiology magazine, April 2017) showed that the protective effects of Tribulus Terrestris (which improves human sperm motility and viability) may be due to its antioxidant properties. On the basis of the results, the researchers concluded that the plant can be used as a safe therapeutic alternative to current modalities for the management of motility dysfunction in males. The studies show that the plant’s compound protodioscin is metabolized in the body to dehydroepiandrosterone (DHEA), which has a beneficial effect on the immune system, cell membrane integrity, erectile function, and cholesterol metabolism. Cholesterol is known to be essential for the synthesis of all steroids, including DHEA, testosterone, and estradiol, which explains the hypolipidemic effect of the drug. Other saponin components of the plant enhance the effect of protodioscin. The research showed the effect of a hydroalcoholic extract of Tribulus Terrestris on the serum glucose and lipid profile of women with diabetes mellitus. Tribulus Terrestris extract is to be used as a part of complex therapy of: Erectile dysfunction accompanied by decreased libido; Male infertility due to reduction in the quantity and quality of spermatozoa in the secreted semen, varicocele surgery, or immunological infertility; Dyslipidemia in order to lower cholesterol. Produced by Evalar, Russia.